| 发明名称 | 门冬氨酸鸟氨酸化合物 | ||
| 摘要 | 本发明属于医药技术领域，具体涉及门冬氨酸鸟氨酸水合物化合物，本发明得到的门冬氨酸鸟氨酸水合物化合物，含有一个结晶水，具有的优点：纯度高，稳定性好，在高湿度条件下吸湿增重也不明显，本发明还涉及使用这种水合物制造治疗肝性脑病、慢性乙型肝炎相关疾病药物的应用。 | ||
| 申请公布号 | CN102516106A | 申请公布日期 | 2012.06.27 |
| 申请号 | CN201110343081.1 | 申请日期 | 2011.11.03 |
| 申请人 | 天津市汉康医药生物技术有限公司 | 发明人 | 严洁;黄欣 |
| 分类号 | C07C229/26(2006.01)I;C07C227/42(2006.01)I;A61K31/205(2006.01)I;A61P1/16(2006.01)I;A61P31/20(2006.01)I | 主分类号 | C07C229/26(2006.01)I |
| 代理机构 | 代理人 | ||
| 主权项 | 1.式Ⅰ所示门冬氨酸鸟氨酸水合物化合物，<img file="2011103430811100001DEST_PATH_IMAGE001.GIF" wi="" he="" />（Ⅰ）用卡尔费休法测定，所述水合物含有6.2%—6.5%的水分；所述门冬氨酸鸟氨酸水合物的晶体，用CuKa射线作为特征X射线粉末测定中，其图谱具有下列2θ衍射角和D值，相对强度大于等于30的为：<tables num="0001"><table><tgroup cols="5"><colspec colname="c001" colwidth="13%" /><colspec colname="c002" colwidth="25%" /><colspec colname="c003" colwidth="25%" /><colspec colname="c004" colwidth="19%" /><colspec colname="c005" colwidth="16%" /><tbody><row><entry morerows="1">峰数</entry><entry morerows="1">2θ角（°）实测值</entry><entry morerows="1">d（）实测值</entry><entry morerows="1">强度</entry><entry morerows="1">I/I<sub>0</sub></entry></row><row><entry morerows="1">1</entry><entry morerows="1">7.340</entry><entry morerows="1">12.0338</entry><entry morerows="1">6056</entry><entry morerows="1">65</entry></row><row><entry morerows="1">2</entry><entry morerows="1">9.000</entry><entry morerows="1">9.8176</entry><entry morerows="1">3069</entry><entry morerows="1">33</entry></row><row><entry morerows="1">3</entry><entry morerows="1">9.240</entry><entry morerows="1">9.5631</entry><entry morerows="1">5497</entry><entry morerows="1">59</entry></row><row><entry morerows="1">4</entry><entry morerows="1">12.920</entry><entry morerows="1">6.8464</entry><entry morerows="1">2905</entry><entry morerows="1">31</entry></row><row><entry morerows="1">5</entry><entry morerows="1">13.260</entry><entry morerows="1">6.6716</entry><entry morerows="1">3420</entry><entry morerows="1">36</entry></row><row><entry morerows="1">6</entry><entry morerows="1">14.580</entry><entry morerows="1">6.0704</entry><entry morerows="1">6547</entry><entry morerows="1">70</entry></row><row><entry morerows="1">7</entry><entry morerows="1">15.600</entry><entry morerows="1">5.6757</entry><entry morerows="1">7683</entry><entry morerows="1">82</entry></row><row><entry morerows="1">8</entry><entry morerows="1">15.900</entry><entry morerows="1">5.5693</entry><entry morerows="1">4945</entry><entry morerows="1">53</entry></row><row><entry morerows="1">9</entry><entry morerows="1">17.900</entry><entry morerows="1">4.9513</entry><entry morerows="1">9383</entry><entry morerows="1">100</entry></row><row><entry morerows="1">10</entry><entry morerows="1">18.520</entry><entry morerows="1">4.7869</entry><entry morerows="1">8323</entry><entry morerows="1">89</entry></row><row><entry morerows="1">11</entry><entry morerows="1">19.420</entry><entry morerows="1">4.5670</entry><entry morerows="1">2955</entry><entry morerows="1">31</entry></row><row><entry morerows="1">12</entry><entry morerows="1">20.300</entry><entry morerows="1">4.3710</entry><entry morerows="1">2858</entry><entry morerows="1">30</entry></row><row><entry morerows="1">13</entry><entry morerows="1">21.280</entry><entry morerows="1">4.1719</entry><entry morerows="1">9169</entry><entry morerows="1">98</entry></row><row><entry morerows="1">14</entry><entry morerows="1">22.040</entry><entry morerows="1">4.0297</entry><entry morerows="1">2785</entry><entry morerows="1">30</entry></row><row><entry morerows="1">15</entry><entry morerows="1">22.440</entry><entry morerows="1">3.9588</entry><entry morerows="1">8853</entry><entry morerows="1">94</entry></row><row><entry morerows="1">16</entry><entry morerows="1">22.840</entry><entry morerows="1">3.8903</entry><entry morerows="1">3308</entry><entry morerows="1">35</entry></row><row><entry morerows="1">17</entry><entry morerows="1">23.180</entry><entry morerows="1">3.8340</entry><entry morerows="1">5284</entry><entry morerows="1">56</entry></row><row><entry morerows="1">18</entry><entry morerows="1">24.100</entry><entry morerows="1">3.6897</entry><entry morerows="1">3999</entry><entry morerows="1">43</entry></row><row><entry morerows="1">19</entry><entry morerows="1">25.620</entry><entry morerows="1">3.4741</entry><entry morerows="1">4654</entry><entry morerows="1">50</entry></row><row><entry morerows="1">20</entry><entry morerows="1">26.040</entry><entry morerows="1">3.4190</entry><entry morerows="1">3202</entry><entry morerows="1">34</entry></row><row><entry morerows="1">21</entry><entry morerows="1">27.680</entry><entry morerows="1">3.2201</entry><entry morerows="1">4404</entry><entry morerows="1">47</entry></row><row><entry morerows="1">22</entry><entry morerows="1">32.100</entry><entry morerows="1">2.7861</entry><entry morerows="1">3494</entry><entry morerows="1">37</entry></row></tbody></tgroup></table></tables>。 | ||
| 地址 | 300203 天津市河西区大沽南路敬重里4号3层 | ||