| 摘要 |
FIELD: medicine. ^ SUBSTANCE: present invention refers to a controlled-release excipient composition to be used for preparing delayed- or prolonged-release tablets, wherein the composition contains a synergic mixture of essentially non-cross-linked carboxymethyl starch or sodium starch glycolate (SSG) and hydrophilic non-ionogenic cellulose ester, preferentially hydroxypropyl methyl cellulose. Sedimentation is used to specify whether SSG appears to be adequately non-cross-linked for the purposes of the present invention, more specifically: the preparation 0.25 g in deionised water 100 ml every 24 h at 25C, in case of centrifugation at 6080 G and 25C for 15 min shall produce a sedimentation volume min. 60 ml. The invention also concerns a formulation of the delayed- or prolonged-release tablet which contains the excipient presented by carboxymethyl starch and cellulose ester, and additionally contains one or more active substances. ^ EFFECT: developing the controlled-release excipient composition. ^ 7 cl, 7 tbl, 8 ex |
