摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a compound of formula I: ^ , where A denotes CH or N; R1 is selected from a group consisting of: cycloalkyl which is unsubstituted or substituted with hydroxy, lower hydroxyalkyl or lower alkoxy, 1-hydroxy-2-indanyl, lower hydroxyalkyl, lower hydroxy haloalkyl, lower hydroxy alkoxyalkyl, CH2-CR9R10-cycloalkyl and -CR11R12- COOR13; R9 denotes hydrogen or lower alkyl; R10 denotes hydrogen, hydroxy or lower alkoxy; R11 and R12 independently denote hydrogen or lower alkyl; R13 denotes lower alkyl; R2 denotes hydrogen; or R1 and R2 together with the nitrogen atom with which they are bonded form a morpholinyl ring; R15 is selected from a group consisting of lower alkoxyalkyl, cycloalkyl and furanyl, substituted with halogen; R17 is selected from a group consisting of hydrogen, lower alkyl and lower haloalkyl; R4 and R8 independently denote hydrogen or halogen; R5 and R7 are independently selected from a group consisting of hydrogen, lower alkyl, lower alkoxy, halogen, lower haloalkyl, lower haloalkoxy and cyano; R6 is selected from a group consisting of hydrogen, lower alkoxy, halogen, lower haloalkyl, lower haloalkoxy and cyano; and pharmaceutically acceptable salts thereof. The invention also relates to use of said compounds to produce medicinal agents for treating and/or preventing diseases which can be cured by HDL-cholesterol raising agents and to a pharmaceutical composition based on said compounds. ^ EFFECT: novel compounds which can be useful in treating diseases which can be treated with HDL-cholesterol raising agents are obtained and described. ^ 36 cl, 164 ex |