发明名称 |
Immunogenic agent and pharmaceutical composition for use against homologous and heterologous pathogens including plasmodium SPP |
摘要 |
The present invention relates to an immunogenic agent comprising a low dose of an antigenic component from one or more pathogens and an agent capable of increasing an amount of IL-12 in animal, and use thereof for reducing infection or improving recovery from an infection from the pathogen. The immunogenic agent preferably comprises CpG nucleic acid, IL-12 protein and/or IL-12 nucleic acid. The pathogen is preferably an intracellular pathogen comprising one or more species and strains, such as Plasmodium spp. The invention also relates to a pharmaceutical composition comprising the immunogenic agent. The pharmaceutical composition is preferably an immunotherapeutic composition. The immunotherapeutic composition, is preferably a vaccine capable of providing protection against or treating Plasmodium spp infection, the causative agent of malaria in humans. |
申请公布号 |
US8206725(B2) |
申请公布日期 |
2012.06.26 |
申请号 |
US20040569703 |
申请日期 |
2004.06.30 |
申请人 |
GOOD MICHAEL;STEVENSON MARY M;THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH;MCGILL UNIVERSITY |
发明人 |
GOOD MICHAEL;STEVENSON MARY M |
分类号 |
A61K39/015;A01N63/00;A01N65/00;A61K39/00;C07K16/20 |
主分类号 |
A61K39/015 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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