19-NOR-STEROID DERIVATIVES WITH A 15,16-METHYLENE GROUP AND A SATURATED 17,17-SPIROLACTONE RING, USE THEREOF, AND MEDICAMENTS CONTAINING SAID DERIVATIVE

摘要

The invention relates to 15α, 16α-methylene-17-hydroxy-19-nor-17-pregna-4-en-3-one-21-carboxylic acid γ-lactone derivatives having a gestagen effect. They are of general chemical formula (I) wherein Z is selected from the group comprising an oxygen atom, two hydrogen atoms, NOR and NNHSOR wherein R is hydrogen, C-Calkyl, aryl or C-C-aralkyl, Ris hydrogen or halogen, and additionally either: R, Rtogether form methylene or 1,2-ethanediyl or Ris hydrogen and Ris selected from the group comprising hydrogen, C-Calkyl, C-Calkenyl or C-Calkinyl, and Ris selected from the group comprising hydrogen, C-Calkyl, C-Ccycloalkyl, C-Calkenyl or C-Calkinyl, or: Ris hydrogen and Rand Rtogether form a bond, an oxygen or methylene, and Ris hydrogen or C-Calkyl. The invention also relates to the solvates, hydrates, stereoisomers and salts of said derivatives., (I)