CHITOSAN MICROGELS CROSS-LINKED WITH GLUTARALDEHYDE AND THE METHOD FOR PRODUCTION THEREOF

摘要

PURPOSE: A chitosan microgel for inclusion of a target material is provided to control release of the target matetial by responding to pH change. CONSTITUTION: A chitosan microgel contains chitosan which is crosslinked with gluta aldehyde, formaldehyde, or dextrin aldehyde. A method for preparing the chitosan microgel comprises: a step of dissolving the chitosan in an acid solution to prepare a chitosan solution; a step of adding a crosslinking agent of gluta aldehyde, formaldehyde, or dextrin aldehyde into the chitosan solution; a step of spray-drying a mixture solution of chitosan and crosslinking agent to prepare crosslinked chitosan microgel; and a step of loading the target material on the chitosan microgel.