发明名称 |
Detection and Quantification of Hydroxymethylated Nucleotides in a Polynucleotide Preparation |
摘要 |
Methods and compositions are described for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation with a view to mapping the location of hmNs in a genome, quantifying the occurrence of hmNs at selected loci and correlating the occurrence of hmNs with gene expression and phenotypic traits. Embodiments describe the use of modifying enzymes together with site-specific endonucleases to detect the hmNs.
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申请公布号 |
US2012156677(A1) |
申请公布日期 |
2012.06.21 |
申请号 |
US201013392286 |
申请日期 |
2010.08.25 |
申请人 |
BITINAITE JURATE;VAISVILA ROMUALDAS;PRADHAN SRIHARSA;ZHENG YU;ROBERTS RICHARD J.;COHEN-KARNI DEVORA;NOREN CHRISTOPHER;RALEIGH ELISABETH A.;WILSON GEOFFREY;CHIN HANG-GYEONG;NEW ENGLAND BIOLABS, INC. |
发明人 |
BITINAITE JURATE;VAISVILA ROMUALDAS;PRADHAN SRIHARSA;ZHENG YU;ROBERTS RICHARD J.;COHEN-KARNI DEVORA;NOREN CHRISTOPHER;RALEIGH ELISABETH A.;WILSON GEOFFREY;CHIN HANG-GYEONG |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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