| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide compositions and methods that are useful in the identification and quantification of any polypeptide or macromolecular complex using a set of co-aptamer constructs. <P>SOLUTION: Aptamer constructs are constructed that bind to unique epitopes of a polypeptide of macromolecular construct. The aptamer constructs contain an epitope binding site, a co-aptamer binding site, and a detectable label. In the presence of the cognate polypeptide, analyte-polypeptide complex, or other macromolecular complex, the co-aptamers associate with one another to produce a detectable signal. The co-aptamer constructs may be joined by a linker to produce a bivalent aptamer construct. <P>COPYRIGHT: (C)2012,JPO&INPIT |
