DRUG FORMULATIONS USING WATER SOLUBLE ANTIOXIDANTS
摘要
<p>The present invention relates to solid, semisolid, or liquid formulations comprising water soluble antioxidants that prevent or reduce formic acid and/or formyl species generation in the dosage form during the manufacturing process and/or during shelf-life storage. The formulations of the present invention prevent or reduce formation of N-formyl impurities (and gelatin crosslinking) during the manufacturing process and/or during shelf-life storage.</p>
申请公布号
WO2012031124(A3)
申请公布日期
2012.06.21
申请号
WO2011US50212
申请日期
2011.09.01
申请人
BRISTOL-MYERS SQUIBB COMPANY;ASTRAZENECA UK LIMITED;NARANG, AJIT;RAO, VENKATRAMANA, M.;DESAI, DIVYAKANT, S.
发明人
NARANG, AJIT;RAO, VENKATRAMANA, M.;DESAI, DIVYAKANT, S.