发明名称 |
INSECTICIDE CRY PROTEINS OF BACILLUS THURINGIENSIS WITH ANTI-CANCER ACTIVITY |
摘要 |
The invention relates to nucleic acid molecules coding for insecticidal proteins of the Cry family, derived from Bacillus thuringiensis, exhibiting cytotoxic activity against cancer and/or tumour cells of humans and/or animals, but not against normal cells. The invention also provides proteins and compositions of proteins of the Cry family, derived from the bacteria Bacillus thuringiensis, that exhibit cytotoxic activity preferably against cancer cells of humans and/or animals, without affecting the normal cells. The Cry proteins of the invention do not exhibit any hemolytic activity, nor do they belong to the parasporin group. The invention also relates to methods for treating cancer and/or tumour cells of humans and/or animals, and for preventing metastasis, using insecticidal Cry proteins of Bacillus thuringiensis. |
申请公布号 |
WO2012080985(A2) |
申请公布日期 |
2012.06.21 |
申请号 |
WO2011IB55722 |
申请日期 |
2011.12.16 |
申请人 |
CENTRO DE INVESTIGACION CIENTIFICA Y DE EDUCACIONSUPERIOR DE ENSENADA, BAJA CALIFORNIA;OLMOS SOTO, JORGE;ARIAS BANUELOS, EFRAIN;MENDOZA ALMANZA, GRETEL |
发明人 |
OLMOS SOTO, JORGE;ARIAS BANUELOS, EFRAIN;MENDOZA ALMANZA, GRETEL |
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