| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method of determining a risk of pouchitis development following a surgical procedure where an internal pouch is created in a patient with ulcerative colitis. <P>SOLUTION: The method is practiced by determining in the patient the presence or absence of a pouchitis-associated allele linked to an interferon gamma receptor locus, where the presence of the pouchitis-associated allele indicates an increased risk of pouchitis development. The interferon gamma receptor locus to which the pouchitis-associated allele is linked can be, for example, an interferon gamma receptor 1 gene. A useful pouchitis-associated allele can be, for example, an allele located within the sixth intron of the interferon gamma receptor 1 gene, such as a FA1 microsatellite 171 allele. <P>COPYRIGHT: (C)2012,JPO&INPIT |
