发明名称 |
SYNTHETIC PEPTIDE INHIBITORS OF WNT PATHWAY |
摘要 |
A peptide or peptidomimetic comprising the amino acid sequence KKRLSVXLTSSLFR (SEQ ID NO: 1) or the inverse thereof, or comprising at least eight contiguous amino acids of helix C of ß-catenin (SEQ ID NO: 41) or inverse thereof, wherein the peptide or peptidomimetic comprises a total of about 50 or fewer amino acids and inhibits the Wnt pathway, as well as a method of inhibiting the Wnt pathway in a cell, a method of treating or preventing a disease mediated by the Wnt pathway, and related compounds, compositions, and methods. |
申请公布号 |
WO2012082891(A1) |
申请公布日期 |
2012.06.21 |
申请号 |
WO2011US64902 |
申请日期 |
2011.12.14 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;TARASOVA, NADYA I.;PERANTONI, ALAN O.;TANIGAWA, SHUNSUKE |
发明人 |
TARASOVA, NADYA I.;PERANTONI, ALAN O.;TANIGAWA, SHUNSUKE |
分类号 |
C07K14/47 |
主分类号 |
C07K14/47 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|