发明名称 |
PHARMACEUTICAL COMPOSITIONS OF SELECTIVE FACTOR XA INHIBITORS FOR ORAL ADMINISTRATION |
摘要 |
The present invention provides pharmaceutical compositions for oral administration comprising a therapeutically effective amount of a selective factor Xa inhibitor or a pharmaceutically acceptable salt thereof and an enhancer, wherein the enhancer is a medium chain fatty acid or a salt, ester, ether, or derivative of a medium chain fatty acid and has a carbon chain length of from 4 to 20 carbon atoms. The present invention also provides a method for obtaining a reproducible bioavailability of selective factor Xa inhibitor in a subject after oral administration comprising orally administering a pharmaceutical composition as described above. |
申请公布号 |
CA2819108(A1) |
申请公布日期 |
2012.06.21 |
申请号 |
CA20112819108 |
申请日期 |
2011.09.23 |
申请人 |
MERRION RESEARCH III LIMITED |
发明人 |
LEONARD, THOMAS W.;COUGHLAN, DAVID C.;CULLEN, ALAN |
分类号 |
A61K9/22;A61K9/24;A61K31/702;A61P7/02 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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