TISSUE PROFILER - A CONTACT-BASED PIEZOELECTRIC MATRIX SENSING DEVICE AND METHOD FOR AVOIDING FALSE NEGATIVES & FURTHER BIOCHEMICAL CHARACTERIZATION, PROFILING & DIAGNOSIS OF DISEASED TISSUE

摘要

Diagnosis classification and profiling of malignant tissue by surface contact with malignant tissue markers array attached to a multi-channel piezoacoustic sensor designed to detect tissue binding onto the markers. Further, using generalized tissue markers (such as MHC I or CD 44) on each of the array's electrodes to assure tissue bonding, to avoid false negatives. The "generic" interaction signal (RAP) variation / deviation is selected to be lowered than the signal of the interaction of the molecules directed against markers set of malignant tissue, such that detections of "specific" malignant tissue markers stand out from the background signal of general tissue bondage. The all together out-put of the "generic" interaction and the "specific" interaction integrated to provide falls negative-free simultaneous DCP of the sampled tissue.