NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS

摘要

The present invention relates to the use of a thiazolamine derivative for acceleration of the differentiation of cells, characterized in that a 2-thiazolamine derivate of the general formula below is used: in which R1 to R3 are each independently selected from hydrogen, benzyl, aryl and heteroaryl or are absent, where not more than one of the R1 to R3 radicals is hydrogen, and R4 is selected from benzyl, aryl and heteroaryl, where R1 to R4 are each independently optionally substituted by one or more substituents selected from halogen (F, Cl, Br, I), hydroxyl, C1-3-alkyl, C1-3-alkoxy, carboxyl, C1-3-alkylcarbonyl, C1-3-alkoxycarbonyl, nitro, amino, mono- and di-C1-3-alkylamino and cyano, in which the alkyl groups are optionally halogenated; ... (aa) in each case is a single bond or a double bond; n = 0 to 2, where, in the case that n = 1, the R4 radical may be bonded to position 4 or 5 of the thiazole ring and, in the case that n = 2, the R4 radicals are bonded to positions 4 and 5 of the thiazole ring.