发明名称 |
PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE |
摘要 |
This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding &bgr;2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease. |
申请公布号 |
US2012157543(A1) |
申请公布日期 |
2012.06.21 |
申请号 |
US201113333866 |
申请日期 |
2011.12.21 |
申请人 |
WAINER IRVING W.;ZHU WEIZHONG;CHAKIR KHALID;XIAO RUI PING;ABERNETHY DARRELL R.;BEIGI FARIDEH M.;SERVICES, NATIONAL INSTITUTES OF HEALTH;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN |
发明人 |
WAINER IRVING W.;ZHU WEIZHONG;CHAKIR KHALID;XIAO RUI PING;ABERNETHY DARRELL R.;BEIGI FARIDEH M. |
分类号 |
A61K31/137;A61P9/00;A61P9/04;A61P11/00;A61P11/06;C07C215/60 |
主分类号 |
A61K31/137 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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