发明名称 |
DRUG COMPOSITION FOR ANGIOGENESIS THERAPY |
摘要 |
The present invention relates to: drug compositions of angiogenesis therapy that contains gene coding for human prostacyclin synthase (hPGIS) synthesizing prostaglandin I2 with activities of vasodialation and/or anti-platelet aggregation; drug compositions contain adeno-associated virus (AAV) inserted with gene for angiogenesis factors. The administration of the drug compositions into the aimed treatment region results in transfer of AAV type 1-hPGIS to skeletal muscles and induces a notable expression of human PGIS gene in skeletal muscles. The PGI2 is produced by mediation of the gene expression in the muscle cells, secreted, induces vessel-protective, neovascularization and anti-platelet aggregation actions, which lead to an improvement in vascular ischemia.
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申请公布号 |
US2012156170(A1) |
申请公布日期 |
2012.06.21 |
申请号 |
US201013393062 |
申请日期 |
2010.08.30 |
申请人 |
TANABE TADASHI;HUKUDA KEIICHI;KAWAKAMI TAKASHI |
发明人 |
TANABE TADASHI;HUKUDA KEIICHI;KAWAKAMI TAKASHI |
分类号 |
A61K48/00;A61P7/02;A61P9/00;A61P9/08;A61P35/00 |
主分类号 |
A61K48/00 |
代理机构 |
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地址 |
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