PROCESS FOR THE PREPARATION OF AROMATIC THIOL DERIVATIVES BY HYDROGENATION OF DISULFIDES
摘要
The application relates to the preparation of thiophenols by reacting the corresponding disulfide with hydrogen in the presence of a heterogeneous transition metal hydrogenation catalyst. If the reaction is carried out in the presence of an acylating agent such as a carboxylic acid anhydride or halide, an acylated thiophenol is obtained. The pharmaceutically active compound S - [ 2 - [ 1 - ( 2 - ethylbutyl) cyclohexylcarbonylamino] -phenyl] 2 -methylthiopropionate is produced via said process.
申请公布号
WO2012080178(A1)
申请公布日期
2012.06.21
申请号
WO2011EP72470
申请日期
2011.12.12
申请人
F. HOFFMANN-LA ROCHE AG;MAIR, HANS-JUERGEN;REENTS, REINHARD;SCALONE, MICHELANGELO;WANG, SHAONING;ZOGG, ANDREAS
发明人
MAIR, HANS-JUERGEN;REENTS, REINHARD;SCALONE, MICHELANGELO;WANG, SHAONING;ZOGG, ANDREAS