发明名称 |
METHODS AND COMPOSITIONS FOR MODULATION OF BLOOD-NEURAL BARRIER |
摘要 |
Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-α antagonist. |
申请公布号 |
US2012156187(A1) |
申请公布日期 |
2012.06.21 |
申请号 |
US201213407270 |
申请日期 |
2012.02.28 |
申请人 |
ERIKSSON ULF;LAWRENCE DANIEL;SU ENMING JOE;STRICKLAND DUDLEY;YEPES MANUEL;FREDRIKSSON LINDA;LUDWIG INSTITUTE FOR CANCER RESEARCH;THE REGENTS OF THE UNIVERSITY OF MICHIGAN;UNIVERSITY OF MARYLAND, BALTIMORE |
发明人 |
ERIKSSON ULF;LAWRENCE DANIEL;SU ENMING JOE;STRICKLAND DUDLEY;YEPES MANUEL;FREDRIKSSON LINDA |
分类号 |
A61K31/4439;A61K31/404;A61K31/416;A61K31/4412;A61K31/444;A61K31/4709;A61K31/502;A61K31/506;A61K38/49;A61P7/02;A61P7/10;A61P9/00 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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