| 发明名称 |
CYCLOSPORINE ANALOGUE MOLECULES MODIFIED AT AMINO ACID 1 AND 3 |
| 摘要 |
<p>Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula (I). The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.</p> |
| 申请公布号 |
CA2821009(A1) |
申请公布日期 |
2012.06.21 |
| 申请号 |
CA20112821009 |
申请日期 |
2011.12.14 |
| 申请人 |
ISOTECHNIKA PHARMA INC. |
发明人 |
ABEL, MARK D.;FENSKE, BRUCE W.;HEGMANS, ALEXANDER;SUGIYAMA, SHIN;TREPANIER, DAN J.;URE, DAREN R. |
| 分类号 |
C07K7/64;A61K38/12;A61K38/13;C07K1/113 |
主分类号 |
C07K7/64 |
| 代理机构 |
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