摘要 |
FIELD: medicine. ^ SUBSTANCE: group of inventions refers to pharmaceutical industry and medicine and is applicable for producing and using medical immunobiological preparations containing nonpathogenic microorganisms. The compositions (versions) represent a powder containing substances containing nonpathogenic microorganisms dried up in a culture medium specified in a number: Bifidobacterium bacteria and/or Lactobacillus bacteria, and/or species-specific virulent bacteriophages, and/or species-specific bacteriophages with induced virulence or their combinations with the composition containing target additives able to form a stable foam structure, is characterised by porous structure and fragility, has a relative disintegration shrinkage at least 10 %, equivalent pore diameter 10-110 mcm at particle size no more than 100 mcm and a resting angle less than 50 in the following proportions in 1.0 g of the composition: Bifidobacterium bacteria 106-1010 CFU and/or Lactobacillus bacteria 106-1010 CFU, and/or species-specific virulent bacteriophages of Appelman's lytic activity at least 10-4 with respect to test strains and bacterial isolates recovered from a human body, and/or species-specific bacteriophages of induced virulence of Appelman's lytic activity at least 10-4 with respect to test strains and bacterial isolates recovered from a human body, target additives - the rest. ^ EFFECT: invention provides maximally achieved isotropic filling of the set volume of drug containers that provides accurate dosage of nonpathogenic microorganisms. ^ 7 cl, 9 ex |
申请人 |
CHALOV VIKTOR VLADIMIROVICH;ALESHKIN VLADIMIR ANDRIANOVICH;GALIMZJANOV KHALIL MINGALIEVICH;AFANAS'EV STANISLAV STEPANOVICH;RUBAL'SKIJ OLEG VASIL'EVICH;ALEKSANJAN IGOR' JUR'EVICH;AMERKHANOVA ADELAIDA MIKHAJLOVNA;DUBINA DILJARA SHAGIDULLAEVNA;GAVRIN ANDREJ GENNAD'EVICH;ALESHKIN ANDREJ VLADIMIROVICH;ERMOLAEV VITALIJ VITAL'EVICH;PODLEDNEVA NATAL'JA ALEKSANDROVNA;MARTYNOV ANDREJ VIKTOROVICH;LOBACHEV NIKOLAJ VASIL'EVICH;GALIMZJANOVA ALIJA KHALILOVNA;RUBAL'SKIJ EVGENIJ OLEGOVICH;AFANAS'EV MAKSIM STANISLAVOVICH;AFANAS'EV DENIS STANISLAVOVICH |
发明人 |
CHALOV VIKTOR VLADIMIROVICH;ALESHKIN VLADIMIR ANDRIANOVICH;GALIMZJANOV KHALIL MINGALIEVICH;AFANAS'EV STANISLAV STEPANOVICH;RUBAL'SKIJ OLEG VASIL'EVICH;ALEKSANJAN IGOR' JUR'EVICH;AMERKHANOVA ADELAIDA MIKHAJLOVNA;DUBINA DILJARA SHAGIDULLAEVNA;GAVRIN ANDREJ GENNAD'EVICH;ALESHKIN ANDREJ VLADIMIROVICH;ERMOLAEV VITALIJ VITAL'EVICH;PODLEDNEVA NATAL'JA ALEKSANDROVNA;MARTYNOV ANDREJ VIKTOROVICH;LOBACHEV NIKOLAJ VASIL'EVICH;GALIMZJANOVA ALIJA KHALILOVNA;RUBAL'SKIJ EVGENIJ OLEGOVICH;AFANAS'EV MAKSIM STANISLAVOVICH;AFANAS'EV DENIS STANISLAVOVICH |