| 摘要 |
<p>Methods and kits for detecting positive responses to therapies, diagnosing a disease or condition, and detecting impending clinical relapse. The method may feature obtaining a sample from a patient and either detecting a percentage of perforin+ natural killer (NK) cells or detecting a level of perforin expression in the sample. Positive responses to the therapy may be detected if the percentage of perforins NK ceils is greater than or equal to about 75% of total NK ceils or if the level of perforin expression in the sample is within a ievel of perforin expression in a normal sample +/-25%. The disease or condition or impending clinical relapse may be detected if the ievel of perforin expression in the sample is less than a level of perforin expression in a normal sample minus about 25% or the percentage of perforin+ NK ceils is less than about 75% of total NK cells.</p> |
