Solutions of an NSAID and one or more cyclodextrins

摘要

A liquid composition comprises an aqueous solution of an NSAID and one or more cyclodextrins. Preferably, the NSAID is selected from ibuprofen, ketoprofen, flurbiprofen, diclofenac or naproxen. Preferably, the cyclodextrin is selected from α, β and γ derivatives of methyl cyclodextrin, hydroxyethyl cyclodextrin, hydroxypropyl cyclodextrin, dihydroxypropyl cyclodextrin. Preferably, the ratio of NSAID to cyclodextrin is between 1:0.5 and 1:1.5. The composition may further include a pharmaceutically acceptable buffer, preferably, selected from disodium hydrogen orthophosphate, citric acid or combinations thereof, which may be present at a concentration in the range from about 0.03% to 5.0%w/v. Preferably the liquid composition is for use in the treatment of sore throat. A method of improving the stability of flurbiprofen when in solution wherein the solution includes compounds bearing a hydroxyl group which do not act as a solvent and wherein the method includes the step of mixing the flurbiprofen with a cyclodextrin prior to the addition of the compounds bearing a hydroxyl group is also outlined.