发明名称 |
PYRIMIDONE DERIVATIVES USED AS TAU PROTEIN KINASE 1 INHIBITORS |
摘要 |
<p>A pyrimidone derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents hydrogen atom and Y represents hydroxyl group, or X represents fluorine atom and Y represents hydrogen atom; R1 represents a C1-6 alkyl group; R2 represents a morpholin-4-yl group which may be substituted, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).</p> |
申请公布号 |
EP2464639(A1) |
申请公布日期 |
2012.06.20 |
申请号 |
EP20100748155 |
申请日期 |
2010.08.11 |
申请人 |
MITSUBISHI TANABE PHARMA CORPORATION;SANOFI |
发明人 |
SAKAI, DAIKI;NAKAYAMA, KAZUKI;WATANABE, KAZUTOSHI |
分类号 |
C07D401/04;A61K31/513;A61P25/16;A61P25/24;A61P25/28;A61P33/06;A61P35/00;C07D413/04;C07D413/14 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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