| 摘要 |
A method for diagnosing a subject suffering from a plasma cell disorder, such as multiple myeloma, amyloidosis, Waldenstromâ s macroglobulinemia, osteosclerotic myeloma (POEMS syndrome), monoclonal gammopathy of unknown significance (MGUS) or plasma cell myeloma, comprising analysing the concentration of one or more microRNA (miRNA) molecules in a sample. The miRNA may be selected from miRNA-15a, miRNA-15b, miRNA-16 and miRNA-221. Also claimed are methods of determining the efficacy of treating a plasma cell disorder with a therapeutic agent, and kits for carrying out the assays and methods. The assays are qualitative and/or quantitative, and are adaptable to large-scale screening and clinical trials. |
