| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to organic chemistry and specifically to a method of producing benzimidazole derivatives of formula where X is a single bond, involving reaction of nitriles, selected from: 3-phenoxybenzonitrile, 3-phenoxyphenyl acetonitrile, 3-(3-phenoxyphenyl)acrylonitrile, 3-(3-phenoxyphenyl)-2-butenonitrile, 3-(3- phenoxyphenyl)propionitrile, 3-(3-phenoxybenzylamino)propionitrile, 2-methyl-2-(3-phenoxybenzoate)propionitrile, 3-phenoxyphenyl methoxypropionitrile with ortho-phenylene diamine hydrochloride in a sealed glass bulb. The process is carried out with molar ratio of nitrile to ortho-phenylene diamine hydrochloride of 1:1.2 at temperature 190-200C. ^ EFFECT: novel method of producing said compound with good output and high degree of purity. |
