| 摘要 |
PURPOSE: A novel hydrazine derivative compound and a composition containing the same are provided to prevent or treat varous diseases relating to a P2X7 receptor. CONSTITUTION: A hydradrazine derivative is denoted by chemical formula 1. A composition for preventing or treating chronic inflammatory diseases, inflammatory pain, neuropathic pain, autoimmune diseases, or degenerative diseases contains the hydrazine derivative as an active ingredient. The autoimmune diseases include rheumatoid arthritis, psoriasis, allergic dermatitis, multiple sclerosis, or asthma. The chronic inflammatory diseases are chronic obstructive pulmonary disease, airways hyper-responsiveness, septic shock, glomerulonephritis, inflammatory bowel diseases(inflammation), Crohn's disease, ulcerative colitis, atherosclerosis, myoblastic leukemia, diabetes, burn, ischemic heart disease, stroke, or varicose vein. |
