POLYPEPTIDE AND ANTIBODY DERIVED FROM CHRONIC LYMPHOCYTIC LEUKEMIA CELLS AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide polypeptides and antibodies derived from chronic lymphocytic leukemia cells, and to provide use thereof.

SOLUTION: There is provided a method of treating cancer which method includes a step for administering to a subject afflicted with cancer a therapeutic composition that (i) interferes the interaction between CD200 and a CD200 receptor thereby inhibiting the immune suppressing effect of CD200 and (ii) kills cancer cells by using a polypeptide fusion molecule that includes a portion binding to OX-2/CD200 or an OX-2/CD200 receptor.

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