摘要 |
<p>The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further objects of the present invention are pharmaceutically acceptable complexes of vildagliptin and/or amorphous and crystalline forms, anhydrous forms, amorphous and crystalline hydrates, amorphous and crystalline solvates of the complexes and a process for the preparation thereof. Another object of the present invention is the high purity vildagliptin and pharmaceutically acceptable salts thereof prepared form the vildagliptin complexes of the present invention, a process for the preparation thereof and pharmaceutical compositions containing vildagliptin base, pharmaceutically acceptable salts and/or complexes and use thereof for the treatment of type 2 diabetes (NIDDM). The present invention provides pharmaceutically advantageous high purity vildagliptin complexes.</p> |
申请人 |
EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZVENY-TARSASAG;MRAVIK, ANDRAS;KOEHEGYI, IMRE;PONGO, LASZLO;VOLK, BALAZS;NEMETH, GABOR;BARKOCZY, JOZSEF;NAGY, KALMAN;RUZSICS, GYOERGY;BRODA, JUDIT;DANCSO, ANDRAS;KESZTHELYI, ADRIENN;DEBRECZENI, JOZSEF |
发明人 |
MRAVIK, ANDRAS;KOEHEGYI, IMRE;PONGO, LASZLO;VOLK, BALAZS;NEMETH, GABOR;BARKOCZY, JOZSEF;NAGY, KALMAN;RUZSICS, GYOERGY;BRODA, JUDIT;DANCSO, ANDRAS;KESZTHELYI, ADRIENN;DEBRECZENI, JOZSEF |