发明名称 |
METHODS FOR TREATING A TUMOR USING AN ANTIBODY THAT SPECIFICALLY BINDS GRP94 |
摘要 |
Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated BRAF. Methods are disclosed for treating a subject diagnosed with a tumor that expresses a mutated BRAF. The methods include administering to the subject (1) a therapeutically effective amount of an antibody or antigen binding fragment thereof that specifically binds glucose regulated protein (GRP) 94; and (2) a therapeutically effective amount of a BRAF inhibitor. In some embodiments, the tumor is melanoma. In some embodiments the method includes selecting a subject with primary or secondary resistance to a BRAF inhibitor. In further embodiments, treating the tumor comprises decreasing the metastasis of the tumor. In additional embodiments, the BRAF inhibitor comprises PLX4032 or PLX4720.
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申请公布号 |
US2012148598(A1) |
申请公布日期 |
2012.06.14 |
申请号 |
US201113309490 |
申请日期 |
2011.12.01 |
申请人 |
FERRONE SOLDANO;WANG XINHUI;FAVOINO ELVIRA;YU LING;WANG YANGYANG;UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
FERRONE SOLDANO;WANG XINHUI;FAVOINO ELVIRA;YU LING;WANG YANGYANG |
分类号 |
A61K39/395;A61P35/00;A61P35/04 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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