IMMUNE RESTRICTED PEPTIDES WITH INCREASED EFFICACY

摘要

The present invention relates to immune restricted peptides, and especially HLA-A2 restricted peptides. Specifically, the present invention relates to immune restricted peptide according to the general formula: (I) wherein: P1 is a naturally, or non-naturally, occurring amino acid comprising a hydrophobic linear aliphatic, aromatic or heteroaromatic substitution; P2 is a naturally, or non-naturally, occurring amino acid comprising a hydrophobic linear or branched substitution; P3 is a naturally, or non-naturally, occurring amino acid comprising a hydrophobic linear or branched substitution; P4 is a naturally, or non-naturally, occurring amino acid comprising a methylated alpha nitrogen atom; Pm is a naturally occurring amino acid, n is an integer of 1 to 9, preferably 1 to 4, more preferably 2 or 3; PC-2 is a naturally, or non-naturally, occurring amino acid comprising a fluorinated aromatic substitution; PC-1 is a naturally, or non-naturally, occurring amino acid; PC is a naturally, or non-naturally, occurring amino acid comprising unsaturated side chains and/or carboxyl isoesters; under the condition that at least one of P1, P2, P3, P4, PC-2 and PC is a non-naturally occurring amino acid.