发明名称 |
Novel viral vector construct for neuron specific continuous DOPA synthesis in vivo |
摘要 |
The present invention relates to a one-vector expression system comprising a sequence encoding two polypeptides, such as tyrosine hydroxylase (TH) and GTP- cyclohydrolase 1 (GCH1 ). The two polypeptides can be should preferentially be expressed at a ratio between 3:1 and 15:1, such as between 3:1 and 7:1. The invention is useful in the treatment of catecholamine deficient disorders, such as dopamine deficient disorders including but not limited to Parkinson's Disease. Moreover, the present invention provides a method to deliver the vector construct in order to limit the increased production of the catecholamine to the cells in need thereof. |
申请公布号 |
AU2010316982(A1) |
申请公布日期 |
2012.06.14 |
申请号 |
AU20100316982 |
申请日期 |
2010.11.09 |
申请人 |
GENEPOD THERAPEUTICS AB |
发明人 |
BJORKLUND, TOMAS;BJORKLUND, ANDERS;KIRIK, DENIZ |
分类号 |
A61K48/00;C12N15/86;C12N15/864 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|