| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide antigens for use in immunisation against pathogenic E. coli strains, particularly ExPEC strains, and more particularly UPEC strains. <P>SOLUTION: The inventors have identified various genes that can be included in immunogenic compositions specific for pathogenic E. coli strains. The genes are from uropathogenic strains (UPEC) but are absent from non-pathogenic strains, and their encoded proteins have cellular locations which render them accessible to the immune system. The present invention also relates to methods for raising an immune response in a patient, comprising the step of administering to the patient a pharmaceutical composition or immunogenic composition. In a particular embodiment, the immune response is protective against ExPEC infection. <P>COPYRIGHT: (C)2012,JPO&INPIT |
