| 发明名称 |
ALPHA-ARYLMETHOXYACRYLATE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME |
| 摘要 |
The present invention relates to an alpha-arylmethoxyacrylate derivative, a preparation method thereof and a pharmaceutical composition comprising the same, and the alpha-arylmethoxyacrylate derivative is inhibitory of HIF, which plays an important role in the regulation of genes associated with energy metabolism, vasomotion, angiogenesis and apoptosis and in the response of cells under hypoxic conditions, so that it can be used for preventing or treating of diseases such as cancer, arthritis, psoriasis, diabetic retinopathy and macular degeneration.
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| 申请公布号 |
US2012149707(A1) |
申请公布日期 |
2012.06.14 |
| 申请号 |
US201113392024 |
申请日期 |
2011.04.21 |
| 申请人 |
KIM SE-WON;KIM JUNG HO;KIM SE-NYUM;KANG DAE-PIL;HAN YOUN HO;JIN GUO FAN;JUNG DONG-SIK;PARK SUNG-HO;KIM JI MIN;ZHENG JHI;OSCOTEC INC. |
发明人 |
KIM SE-WON;KIM JUNG HO;KIM SE-NYUM;KANG DAE-PIL;HAN YOUN HO;JIN GUO FAN;JUNG DONG-SIK;PARK SUNG-HO;KIM JI MIN;ZHENG JHI |
| 分类号 |
A61K31/24;A61K31/216;A61K31/4453;A61K31/5375;A61P17/06;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P35/02;C07C69/732;C07C69/738;C07C229/34;C07D211/34;C07D295/155;C07D295/192 |
主分类号 |
A61K31/24 |
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