The invention relates to compounds that are analogs of a cyclic peptide, cyclo[EKTOVNOGN], AFPep, that has anti-estrotrophic activity. The analogs of the invention include peptides and petidomimetics that inhibit estrogen receptor dependent cell proliferation. The compounds of the invention are useful for treating cell proliferative disorders or physiological conditions characterized by undesirable or unwanted estrogen induced cell proliferation, including breast cancer.
申请公布号
WO2011088462(A3)
申请公布日期
2012.06.14
申请号
WO2011US21560
申请日期
2011.01.18
申请人
ALBANY MEDICAL COLLEGE;ANDERSEN, THOMAS, T.;JACOBSON, HERBERT I.;BENNETT, JAMES A.;JOSEPH, LEROY;BRYAN, ALBERTO
发明人
ANDERSEN, THOMAS, T.;JACOBSON, HERBERT I.;BENNETT, JAMES A.;JOSEPH, LEROY;BRYAN, ALBERTO