发明名称 |
MULTI-DOMAIN AMPHIPATHIC HELICAL PEPTIDES AND METHODS OF THEIR USE |
摘要 |
Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein. |
申请公布号 |
US2012148642(A1) |
申请公布日期 |
2012.06.14 |
申请号 |
US201213407132 |
申请日期 |
2012.02.28 |
申请人 |
REMALEY ALAN T.;DEMOSKY STEPHEN J.;STONIK JOHN A.;AMAR MARCELO J.A.;NEUFELD EDWARD B.;BREWER H. BRYAN;THOMAS FAIRWELL;HEALTH AND HUMAN SERVICES;THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF |
发明人 |
REMALEY ALAN T.;DEMOSKY STEPHEN J.;STONIK JOHN A.;AMAR MARCELO J.A.;NEUFELD EDWARD B.;BREWER H. BRYAN;THOMAS FAIRWELL |
分类号 |
A61K38/16;A61K9/00;A61P3/06;A61P9/00;A61P9/10;C07K14/00;C12Q1/02 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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