| 摘要 |
PURPOSE: An animal models for chronic tympanic membrane perforations is provided to screen a medicine for chronic tympanic membrane perforations and an otitis media. CONSTITUTION: The device is comprised of steps: making an ear drum damaged by heat in punching the ear drum of an animal; processing mitomycin on the punched region; and processing dexmethasone on the processed era drum. A heat-treated tool is used in punching the ear drum to make the ear drum damaged. .
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