摘要 |
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models are disclosed. The presently disclosed mimetic peptides also exhibit anti-lymphangiogenic and directly anti-tumorigenic properties. |
申请人 |
POPEL, ALEKSANDER, S.;ROSCA, ELENA, V.;KOSKIMAKI, JACOB, E.;RIVERA, CORBAN, G.;PANDEY, NIRANJAN, B.;TAMIZ, AMIR, P.;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
POPEL, ALEKSANDER, S.;ROSCA, ELENA, V.;KOSKIMAKI, JACOB, E.;RIVERA, CORBAN, G.;PANDEY, NIRANJAN, B.;TAMIZ, AMIR, P. |