BLADDER CANCER DIAGNOSIS COMPOSITION CONTAINING APE1/REF-1 AND BLADDER CANCER DIAGNOSIS KIT USING SAME

摘要

The present invention relates to a bladder cancer diagnosis composition which contains APE1/Ref-1, a bladder cancer diagnosis kit which contains an antibody which is specifically bonded to APE1/Ref-1, and to a method for measuring the concentration of APE1/Ref-1 in a biological sample through antigen-antibody binding using the antibody which is specifically bonded to APE1/Ref-1. The concentration of APE1/Ref-1 of the present invention significantly increases in a serum of a bladder cancer patient, particularly, in a serum of a patient suffering from bladder cancer of stage 2 or higher than in a serum of a normal person. In addition, when bladder cancer relapses, the concentration of APE1/Ref-1 significantly increases, regardless of the number of relapses, in a serum of a bladder cancer patient than in a serum of an early stage bladder cancer patient who did not experience a relapse of bladder cancer. Accordingly, with APE1/Ref-1 protein of the present invention, bladder cancer may be diagnosed or prognosed in an early stage, and therefore, the APE1/Ref-1 protein of the present invention may be valuably used as a bladder cancer diagnosis marker.