发明名称 |
ONCOLYTIC ADENOVIRUSES FOR TREATING CANCER |
摘要 |
The invention is related to an oncolytic adenovirus that comprises a sequence encoding a hyaluronidase enzyme inserted in its genome. This adenovirus spreads more efficiently in the tumour mass and therefore the oncolytic effect is increased. Injecting the oncolytic adenovirus of the invention endovenously, tumour volume regressions are obtained. Therefore the oncolytic adenovirus of the present invention is useful for the treatment of a cancer or a pre-malignant state of cancer. |
申请公布号 |
US2012148535(A1) |
申请公布日期 |
2012.06.14 |
申请号 |
US201013318876 |
申请日期 |
2010.05.05 |
申请人 |
CARRIO SONIA GUEDAN;PIQUERAS MANEL MARIA CASCALLO;BONATRE RAMON ALEMANY |
发明人 |
CARRIO SONIA GUEDAN;PIQUERAS MANEL MARIA CASCALLO;BONATRE RAMON ALEMANY |
分类号 |
A61K35/76;A61P35/00;C12N7/01 |
主分类号 |
A61K35/76 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|