| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method of evaluating and determining a dialysis membrane, which is conventionally indirectly carried out by measuring TACBUN (time averaged concentration of blood urea nitrogen), by detecting and quantitatively determining kidney failure substances including uremia substances, oxidative stress causing substances, substances accumulating in an autosomal dominant polycystic kidney. <P>SOLUTION: A dialysis membrane is evaluated by detecting or quantitatively determining kidney failure substances present in a test blood sample after hemodialysis. The kidney failure substances include cationic substances (1-methyladenosine, ophthalmic acid, creatinine, 3-methylhistidine, allantoin, trimethylamine-N-oxide, hydroxyproline, citrulline, methionine sulfoxide, asymmetric dimethylarginine, N,N-dimethylglycine, guanidinosuccinic acid, and the like) and anionic substances (cysteine-S-sulfuric acid, 4-hydroxy-3-methoxybenzoic acid, malonic acid, citraconic acid, citric acid, cis-aconitic acid, isocitric acid, 3-indoxyl sulfate, trans-aconitic acid, isethionate, pimelic acid, hippuric acid and the like). <P>COPYRIGHT: (C)2012,JPO&INPIT |
