THERAPEUTIC CONJUGATES OF A DEXTRIN POLYMER AND AN ANTIMICROBIAL PEPTIDE

摘要

The invention concerns a novel anti-microbial peptide (AMP) polymer conjugate comprising at least one AMP, typically colistin, and a dextrin polymer wherein said dextrin polymer has a molecular weight between 5,000-60,000 g/mol and is modified by the additions of pendant groups which increase the stability of the conjugate and so delays its degradation thereby slowing the rate at which the AMP is released.