PHENANTHROINDOLIZIDINE COMPOUND AND NF B INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT

摘要

A novel compound having an excellent NFºB inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof:
wherein, R 1 represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom;
R 2 represents a hydroxyl group, or a lower alkyloky group;
R 3 represents a hydrogen atom, a lower alkyl group, or a halogen atom;
R 4 represents a hydrogen atom or a lower alkyloxy group;
R 5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R 6 or an isopropylidenedioxy group formed together with R 6 ;
R 6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R 5 or an isopropylidenedioxy group formed together with R 5 ;
R 7 represents a hydrogen atom or a lower alkyl group; and
R 8 represents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R 1 , R 3 , R 4 and R 7 are hydrogen atoms, R 2 and R 8 are hydroxyl groups, and R 5 and R 6 are methoxy groups).