发明名称 |
RAPID ESTABLISHMENT AND/OR TERMINATION OF SUBSTANTIAL STEADY-STATE DRUG DELIVERY |
摘要 |
The present invention is directed to treatment methods for a disease or condition, in a subject in need of such treatment, that provide alternatives to treatment by injection that give, relative to treatment by injection, improved treatment outcomes, 100% treatment compliance, reduced side effects, and rapid establishment and/or termination of substantial steady-state drug delivery. The method typically includes providing continuous delivery of a drug from an implanted osmotic delivery device, wherein substantial steady-state delivery of the drug at therapeutic concentrations is typically achieved within about 7 days or less after implantation of the osmotic delivery device in the subject and the substantial steady-state delivery of the drug from the osmotic delivery device is continuous over a period of at least about 3 months. In one embodiment, the present invention is directed to treatment of type 2 diabetes mellitus using incretin mimetics. |
申请公布号 |
EP2462246(A1) |
申请公布日期 |
2012.06.13 |
申请号 |
EP20100819152 |
申请日期 |
2010.09.21 |
申请人 |
INTARCIA THERAPEUTICS, INC |
发明人 |
ALESSI, THOMAS, R.;LUSKEY, KENNETH, L. |
分类号 |
C12Q1/68;A61K9/00;C40B30/04 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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