| 摘要 |
<p>Novel inhibitors of s-nitrosoglutathione reductase (GSNOR) are disclosed that specifically inhibit GSNOR among the alcohol dehydrogenases; methods of using these and related molecules are also disclosed. These inhibitors may interact with the GSNO binding site and inhibit GSNOR at multiple places in its kinetic pathway. These molecules inhibit GSNOR in a dose-dependent manner and demonstrate that GSNOR actively regulates the s-nitrosylation of proteins against incoming low molecular weight nitrosothiols. These compounds are useful in methods of treating, diagnosing and studying various conditions and diseases, including but not limited to Cardiovascular Diseases, Pulmonary Diseases, Urogenital Diseases, Neurologic Diseases, Inflammatory Diseases, and Oncologic Diseases, as well as various genetic conditions. Innovative uses for these compounds include using them to study enzymes involving the s-nitrosylation of proteins and various cellular processes that involve or that are thought to involve the activity of these enzymes.</p> |
