| 发明名称 |
METHOD FOR PRODUCING THERAPEUTIC PROTEINS IN PICHIA PASTORIS LACKING DIPEPTIDYL AMINOPEPTIDASE ACTIVITY. |
| 摘要 |
The present invention related to methods and compositions for producing therapeutic proteins in yeast cell lines, and in particular Pichia pastoris, lacking dipeptidyl aminopeptidase (DAP) activity. DAP activity has been eliminated by genetically modifying a Pichia pastoris cell line such that STE13 and DAP2 have been deleted. |
| 申请公布号 |
MX2012004994(A) |
申请公布日期 |
2012.06.12 |
| 申请号 |
MX20120004994 |
申请日期 |
2010.10.27 |
| 申请人 |
MERCK SHARP & DOHME CORP.* |
发明人 |
STADHEIM, TERRANCE A.;HAMILTON, STEPHEN R. |
| 分类号 |
C12N1/19;C12N15/09 |
主分类号 |
C12N1/19 |
| 代理机构 |
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