发明名称 |
BENZOPYRANYL TETRACYCLES INHIBITING RANKL-INDUCED OSTEOCLASTOGENESIS |
摘要 |
PURPOSE: A novel benzopyranyl tetracycle compound and a method for preparing the same are provided to effectively inhibit RANKL-induced osteoclastogenesis. CONSTITUTION: A novel benzopyranyl tetracycle compound is denoted by chemical formula 1. In chemical formula 1, R1 is hydrogen atom or hydroxyl; R2 and R'2 are identical or different methyl or cyclopentyl; and R3 is phenyl or p-methyl phenyl. A therapeutic agent for treating bone diseases contains the benzopyranyl tetracycle compounds as an active ingredient. The effective dose of the benzopyranyl tetracycle compounds is 1-50mg/kg/day.
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申请公布号 |
KR20120060957(A) |
申请公布日期 |
2012.06.12 |
申请号 |
KR20100092520 |
申请日期 |
2010.09.20 |
申请人 |
SNU R&DB FOUNDATION |
发明人 |
PARK, SEUNG BUM;KIM, SEONG HWAN;ZHU MING YAN;LEE, SANG HEE |
分类号 |
C07D491/147;A61K31/5025;A61P19/08;A61P19/10 |
主分类号 |
C07D491/147 |
代理机构 |
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