发明名称 |
Recombinant gene containing heat-labile enterotoxin B subunit and ApxIIA fragment, transgenic plant expressing LTB-ApxIIA fusion gene, and uses thereof |
摘要 |
PURPOSE: A recombinant plant expression vector having a fusion protein containing E.coli endotoxin B subunit(LTB) gene and an Actinobacillus pleuropneumoniae-derived ApxIIA gene fragment is provided to effectively manufacture a vaccine for pleuropneumonia. CONSTITUTION: A recombinant plant expression vector has a fusion gene containing E.coli-derived endotoxin B subunit(LTB) gene and Actinobacillus pleuropneumoniae-derived ApxIIa gene fragment. The ApxIIA gene fragment is ApxIIA619-801 gene having a base sequence of sequence number 1. A method for preparing the LTB-ApxIIA fusion protein comprises a step of transforming a plant with a vector and expressing the fusion gene. A vaccine composition for pleuropneumonia contains LTB-ApxIIA fusion protein as an active ingredient.
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申请公布号 |
KR20120060334(A) |
申请公布日期 |
2012.06.12 |
申请号 |
KR20100121786 |
申请日期 |
2010.12.02 |
申请人 |
INDUSTRIAL COOPERATION FOUNDATION CHONBUK NATIONAL UNIVERSITY |
发明人 |
YANG, MOON SIK;KIM, TAE GEUM |
分类号 |
C12N15/62;A61K39/116;C07K19/00;C12N15/82 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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