发明名称 |
SINGLE-CHAIN ANTIGEN-BINDING PROTEINS CAPABLE OF GLYCOSYLATION, PRODUCTION AND USES THEREOF |
摘要 |
The present invention relates to single-chain antigen-binding molecules capable of glycosylation. Compositions of, genetic constructions coding for, and methods for producing monovalent and multivalent single-chain antigen-binding molecules capable of glycosylation are described and claimed. Compositions of, genetic constructions coding for, and methods for producing glycosylated monovalent and multivalent single-chain antigen-binding molecules capable of polyalkylene oxide conjugation are described and claimed. The invention also relates to methods for producing a polypeptide having increased glycosylation and the polypeptide produced by the described method. Uses resulting from the multifunctionality of a glycosylated/polyalkylene oxide conjugated antigen-binding protein are also described and claimed.
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申请公布号 |
CA2288992(C) |
申请公布日期 |
2012.06.12 |
申请号 |
CA19982288992 |
申请日期 |
1998.04.30 |
申请人 |
ENZON, INC. |
发明人 |
FILPULA, DAVID R.;WANG, MAOLIANG;SHORR, ROBERT G. L.;WHITLOW, MARC D.;LEE, LIHSYNG S. |
分类号 |
C07K16/00;G01N33/53;A61K39/38;A61K47/48;A61P35/00;C07H21/04;C07K14/00;C07K14/715;C07K16/30;C07K16/44;C07K19/00;C12N1/15;C12N1/19;C12N1/20;C12N1/21;C12N5/10;C12N15/00;C12N15/09;C12P21/02;C12P21/08;C12R1/84;G01N33/68 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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