发明名称 |
NOVEL CRYSTAL FORM OF 5-HYDROXY-1-METHYLHYDANTOIN |
摘要 |
Conventional 1-form crystals of 5-hydroxy-1-methylhydantoin contain, remaining therein in a considerable amount, the organic solvent used in a purification step. In contrast, in II-form crystals, the amount of the organic solvent remaining therein is smaller than the detection limit. Namely, the II-form crystals contain substantially no residual organic solvent. The novel II-form crystals of 5-hydroxy-1-methylhydantoin obtained through recrystallization from water not only contain substantially no residual organic solvent, but also have a high bulk density and are hence advantageous for pharmaceutical preparation. They further have properties advantageous for production, such as low adhesion. The crystals are significantly useful as a material for medicines required to have high safety, such as drugs for renal insufficiency.
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申请公布号 |
CA2479549(C) |
申请公布日期 |
2012.06.12 |
申请号 |
CA20032479549 |
申请日期 |
2003.04.09 |
申请人 |
NIPPON ZOKI PHARMACEUTICAL CO., LTD. |
发明人 |
OKAMOTO, KAORU;NISHIMURA, NAOHARU;ISHII, AKIRA |
分类号 |
C07D233/66;C07D233/72;A61K31/4166;A61P13/12 |
主分类号 |
C07D233/66 |
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